"We live inside a dream.
- But who is the dreamer and who is the dream?"
Quantum mechanics shows observing events changes the events themselves, but go one step further. Remove all sentient beings from this planet. The universe could then be a realm of potentialities, superpositions, with deep, deep time just matter and energy degrading down to radiation. Black holes fizzle out. Not even light exists, just a soup of radiation.
So if the lifespan of all life in the universe and the lifespans of all matter within it is akin to one frame in a larger set of 10 to the power of infinity, where time loses all meaning, where space that is also expanding faster and faster to the point of being unquantifiable, reality as as human construct is just one frame among infinite others where there is no consciousness and where the reality we construct is long, long extinct.
You could say this makes everything futile, but alternatively it's what adds so much meaning and joy to this part of the flash that we inhabit.
There's also the small matter of whether we occupy base-line reality, or are a simulation. Add Susskind's holographic universe hypothesis and the human mind can barely take that in, or as Robert AW stated, reality is where the last group of shamans fought to a standstill.
I'd call these white pills.