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mixed_biscuits

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Has this happened with any of the many viral vaccines we've been using routinely for decades?
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

concern for an inappropriate response among persons vaccinated with a SARS-CoV vaccine emanated from experiences with coronavirus infections and disease in animals that included enhanced disease among infected animals vaccinated earlier with a coronavirus vaccine [31]. Feline infectious peritonitis coronavirus (FIPV) is a well-known example of antibody-mediated enhanced uptake of virus in macrophages that disseminate and increase virus quantities that lead to enhanced disease [31], [45]. Antigen-antibody complex formation with complement activation can also occur in that infection and some other coronavirus infections in animals. Thus, concern for safety of administering SARS-CoV vaccines to humans became an early concern in vaccine development.
 

WashYourHands

Cat Malogen
Exactly.....caution

Conclusions​

These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.
 

mixed_biscuits

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Yeah, I wouldn't characterise our response as one demonstrating a great deal of 'caution': we're second most advanced in vaccination rollout and everything is done sloppily under unusual emergency legislation with no-one taking responsibility for any ill effects.
 

version

Well-known member
Except maybe Peter Thiel, obviously.
co-vampire.jpg
 

Leo

Well-known member
I think it's a minimalist assertion that there is no evidence for it with the unstated caveat that only long-term data would provide any evidence.

A bit like saying, 'There is no current evidence that standing in the motorway is a risk' just because the articulated lorry hasn't hit me yet.

not really. everyone knows there's tons of risk in standing in a motorway, and lots of evidence of that risk.

and of course, long-term data could prove things we don't know now, is anyone actually arguing against that? but every decision in life is a weighing of risk and reward. you don't have to get vaccinated. roll the dice, take yr chances.
 

Leo

Well-known member
Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

concern for an inappropriate response among persons vaccinated with a SARS-CoV vaccine emanated from experiences with coronavirus infections and disease in animals that included enhanced disease among infected animals vaccinated earlier with a coronavirus vaccine [31]. Feline infectious peritonitis coronavirus (FIPV) is a well-known example of antibody-mediated enhanced uptake of virus in macrophages that disseminate and increase virus quantities that lead to enhanced disease [31], [45]. Antigen-antibody complex formation with complement activation can also occur in that infection and some other coronavirus infections in animals. Thus, concern for safety of administering SARS-CoV vaccines to humans became an early concern in vaccine development.

this is from 2012. has anything changed in nearly a decade?
 

Mr. Tea

Let's Talk About Ceps
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