I think for full on deep end tripping it would take a long time to get there even for someone born into a meditating culture and practising from childhood. Also, I don't know if the visuals etc would be the same. I'm going to have a Google now actually. Different hallucinogens have different visual styles, right? Sometimes when you mix them whole new things come out too. I suspect a scientific rationalist would have quite a tough time breaking through, though ;p I highly recommend a 10 day Vipassana course at least one time in your life. That will give you a taste of the possibilities. Just go in there and try to minimize expectations as much as realistically possible. I did it and had some experiences that formed my way of thinking about all that you stand against lol. I was a hopeful sceptic before Vipassana and then it basically let me know that, actually, there are whole other worlds of perception we can tap into. And all the other stuff like trancending the physical. Connection to, and being one with the other 200 people in the room. But not in the cheesy sense. I really want to go back.