Yeah perhaps postmodernism can be figured as the recoil from the sensation that not all knowledge is confined to factuality. Like if someone needs emprical proof for the existence of god, and just continue to drift into depsondancy and alienation within their overly scientific project of total knowledge, they would exhibit symptoms that are microcosmically analogous to postmodernism.
Anyway, yeah I see the dominance of science over gnosis, within the pursuit of total knowledge, to give rise to something like postmodernism culturally and ideologically.